Protein Details: Aquaporin-0

Protein ID

ICDB_Pro_0315

Protein Name

Aquaporin-0

Gene Name

Mip

Organism

Rattus norvegicus (Rat)

Length

261 amino acids

AlphaFoldDB

AF-P09011-F1-model_v4.pdb

Function

Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity).

Sequence

ELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVALAFGLALATLVQTVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYIAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHAGVSVGQATTVEIFLTLQFVLCIFATYDERRNGRMGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFSNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSVSERLSILKGARPSDSNGQPEGTGEPVELKTQAL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 147: "Important for water channel gating"; SITE 244: "Interaction with BFSP1"; SITE 248: "interaction with BFSP1";

Disease

Location

Major component of lens fiber gap junctions

DOI ID

10.1093/nar/18.14.4256; 10.1042/bj3050753; 10.1093/nar/16.19.9348